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KMID : 0388420010110010047
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Konkuk Journal of Medical Sciences
2001 Volume.11 No. 1 p.47 ~ p.52
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The effect of Lispro insulin and Regular insulin on Continuous Subcutaneous Insulin Infusion therapy in Korea Type 2 diabetic patients
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Yu Jae-Deung
Park Bong-An
Ryu Ha-Kun
Ryu Ju-Sung
Kim Jung-Su
Kim Chi-Hun
Park Sun-Min
Choi Soo-Bong
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Abstract
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Objective: The Lispro insulin has faster onset of effects and shorter duration than the human regular insulin, an analog of human insulin. The differences in the pharmacodynamics between the two types of insulin in the continuous subcutaneous insulin infusion(CSII) with insulin pump for treating the Korean Type 2 DM patients were analyzed. The effects on the regulation of blood, sugar, the amount of insulin injected, and the frequency of hypoglycemia were compared between the lispro insulin and the regular human insulin.
Method and Materials: One hundred and three Korean Type 2 DM patients were randomly divided into two groups, 49 Lispro insulin and 54 Regular insulin. (Table 1) Both groups were treated for 14 days. Also at a set time before meal, insulin was injected as bolus, using a portable insulin pump, in both groups, 15 minutes before for lispro insulin and 30 minutes before for human insulin. The HbA1C, C-peptide, AC/PC, height and weight were measured for each patients at the time of admission. The peripheral blood sugar level and insulin injection profile were recorded 7 times per day for each patients.
Results: After treating for 7 days and 14 days, the blood sugar level normalized in both groups. There weren’t any significant differences in blood sugar levels in both groups at point of the study, and also there weren’t any differences in the frequency of hypoglycemia. In order to maintain the normalized blood sugar level, the lispro insulin group had higher total daily insulin requirement than the regular insulin group after 14 days of treatment (0.90±0.35 vs 0.73±0.39u/kg/day, p<0.05). This difference is probably due to the difference in basement insulin requirements rather than prandial insulin requirements (0.32±0.1 vs 0.43±0.09u/kg/day, p<0.001).
Discussion: In the hospitalized Korean Type 2 DM patients with CSII treatment, continuous subcutaneous insulin infusion therapy using lispro insulin has convenience in usage compared to the regular insulin. However, there were not any differences in the blood sugar levels. Also lispro insulin requires more insulin in order to maintain normal blood sugar level, which is probably due to the increase in the basal requirement. Also there were not any difference in the frequency of hypoglycemia.
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KEYWORD
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CSII, lispro insulin, regular insulin
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